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KMID : 0358319970380050523
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Korean Journal of Urology
1997 Volume.38 No. 5 p.523 ~ p.527
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The Efficacy of intranasal Desmopressin in the Treatment of Nocturnal Enuresis
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Abstract
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The treatment of choice for primary nocturnal enuresus(PNE) in Korea remains imipramine which has proven to be effective in approximately 50 to 80%, but it is an antidepressant with toxic side effects and risk of overdose. Recently desmopressin
(DDAVP,
1-desamino-8-D-arginine-vasopressin) has been introduced for the treatment and its effect has been promising in many reports.
To find the efficacy and safety of intranasal desmopressin, we evaluated the results of therapy in 48 enuretic children (34 boys and 14 girls). Mean age was 9.8 years(range 5-16). All the children were evaluated at least 3 months after the
treatment
with intranasal desmopressin.
The overall response rate was 83.3%. The number of wet night per week before and after intranasal desmopressin treatmint was 6.42 and 1.83 nights per week respectively. No side effects were observed.
These data shows that the intranasal desmopressin therapy is effective and safe for the treatment of PNE.
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